Moderators of antidepressant augmentation versus switch in the OPTIMUM randomised controlled trial
Augmenting was superior to switching antidepressants only in older patients with fewer than three previous antidepressant trials. This suggests that other intervention strategies should be considered following three or more trials.
Authors
- Steven P. Roose
- Jordan F. Karp (ORCID: https://orcid.org/0000-0002-5171-5028)
- Daniel M. Blumberger (ORCID: https://orcid.org/0000-0002-8422-5818)
- J. Philip Miller (ORCID: https://orcid.org/0000-0003-4568-6846)
- Alastair J. Flint (ORCID: https://orcid.org/0000-0001-6806-0235)
- Benoit H. Mulsant (ORCID: https://orcid.org/0000-0002-0303-6450)
- Eric J. Lenze (ORCID: https://orcid.org/0000-0002-0471-9368)
- Emily Lenard
- Helen Lavretsky (ORCID: https://orcid.org/0000-0001-9990-5085)
- Helena K. Kim (ORCID: https://orcid.org/0000-0002-6578-2109)
- Patrick J. Brown (ORCID: https://orcid.org/0000-0003-3906-6667)
- Charles F. Reynolds
Institutions
- University Health Network (CA)
- Centre for Addiction and Mental Health (CA)
- University of Arizona (US)
- Mental Health Research Institute (AU)
- University of California, Los Angeles (US)
- University of Pittsburgh (US)
- University of Toronto (CA)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- Health Net (US)
- University of California System (US)
- New York Psychoanalytic Society and Institute (US)
Publication Details
- Journal
- The British Journal of Psychiatry
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1192/bjp.2025.125
- Citations
- 2
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Patient-Centered Outcomes Research Institute
- Vanderbilt University
- University of Pennsylvania
- Wake Forest University
- University of Texas Southwestern Medical Center
- University of Toronto
- National Institutes of Health
- University of California, San Francisco
- Canadian Institutes of Health Research