Alzheimer's disease genetic risk: Top African American risk allele frequencies and genetic architecture among Mexican‐, African‐, and non‐Hispanic White Americans
Alzheimer's disease (AD) burden is rapidly increasing in the United States; minorities are disproportionally affected.We investigate genetic health disparities in our community-based diverse cohort.Twelve of 15 evaluated single nucleotide polymorphisms significantly differ among ethnicities in the Health & Aging Brain Study-Health Disparities.
Authors
- Reem Ayoub
- John J. Gutierrez
- Robert C. Barber (ORCID: https://orcid.org/0000-0001-6857-0286)
- Shea J. Andrews (ORCID: https://orcid.org/0000-0002-1921-9470)
- Lubnaa Abdullah (ORCID: https://orcid.org/0000-0002-3664-1075)
- Mohammad Housini (ORCID: https://orcid.org/0000-0003-3597-481X)
- Sid E. O’Bryant (ORCID: https://orcid.org/0000-0003-0582-5266)
- Nicole Phillips (ORCID: https://orcid.org/0000-0002-9324-2687)
- Gita A. Pathak (ORCID: https://orcid.org/0000-0003-3943-0895)
- Zhengyang Zhou (ORCID: https://orcid.org/0000-0002-8039-418X)
Institutions
- University of North Texas (US)
- University of North Texas Health Science Center (US)
- University of California, San Francisco (US)
- Texas College (US)
- Genomic Health (United States) (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70124
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Cancer Prevention and Research Institute of Texas
- National Institutes of Health
- Health Science Center, University of North Texas
- National Institute on Aging