Proteolytic stabilization of a spider venom peptide results in an orally active bioinsecticide
A novel, peptide-based bioinsecticide derived from spider venom was developed to be stable and active by ingestion by lepidopteran pests. The peptide, U1-AGTX-Ta1b-QA, can replace or reduce the use of chemical insecticides and has been approved by the United States Environmental Protection Agency. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Authors
- Alexandra Haase (ORCID: https://orcid.org/0000-0003-2666-4297)
- Daniel Hulbert (ORCID: https://orcid.org/0000-0002-0188-443X)
- Rosemary B. Cornell
- Barry R. Davis (ORCID: https://orcid.org/0000-0002-6943-5673)
- Robert M. Kennedy (ORCID: https://orcid.org/0000-0001-6836-7923)
- Brian T. DeVree (ORCID: https://orcid.org/0000-0003-0582-8125)
- Kyle D. Schneider
- Daniel C. Peck
- Lin Bao
- Trang Nguyen (ORCID: https://orcid.org/0000-0002-8564-3835)
- L. Bell
- Joseph S. Tourtois
- Cadence J. Flohrschutz
Institutions
- Vestaron (United States) (US)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1002/ps.8980
- Citations
- 1
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.81