Elevation of NTN4 Expression and Its Possible Regulation by Tumor Necrosis Factor-Alpha (TNF-α) in a Rat Model of Rotator Cuff Tear
Our findings identify NTN4 as a TNF-α-induced effector that contributes to sustained MMP-3-mediated matrix degradation following rotator cuff tear. By linking inflammatory cytokine signaling to prolonged ECM remodeling, the TNF-α/NTN4/MMP-3 axis may represent a potential therapeutic target for improving tendon healing and reducing re-tear risk.
Authors
- Yui Uekusa
- Masashi Takaso (ORCID: https://orcid.org/0000-0003-2407-9123)
- Tomonori Kenmoku (ORCID: https://orcid.org/0000-0001-8423-5357)
- Ryo Tazawa (ORCID: https://orcid.org/0000-0002-2664-7377)
- Kosuke Inoue (ORCID: https://orcid.org/0000-0001-9614-8103)
- Kentaro Uchida (ORCID: https://orcid.org/0000-0001-5148-914X)
- Mitsuyoshi Matsumoto
Institutions
- Kitasato University (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-06-18
- DOI
- https://doi.org/10.7759/cureus.86324
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science