In vitro activity and in vivo efficacy of omadacycline against Plasmodium species
Omadacycline demonstrated enhanced antimalarial efficacy over doxycycline in vitro in liver stage activity and in overcoming resistance in the blood stage, and in survival in an in vivo model of P. berghei infection. These findings support further investigation of omadacycline as a potential candidate for malaria prophylaxis and treatment.
Authors
- Alisa W. Serio
- Diana Caridha (ORCID: https://orcid.org/0000-0002-9857-0719)
- Jessica V. Pierce
- Susan E. Leed
- Michael S. Madejczyk (ORCID: https://orcid.org/0000-0002-6000-2599)
- Patricia Lee (ORCID: https://orcid.org/0000-0002-8593-2733)
- Karl Kudyba (ORCID: https://orcid.org/0000-0001-5681-321X)
- Alison Roth (ORCID: https://orcid.org/0000-0001-6917-3485)
- Diane Anastasiou
- Monica L. Martin
Institutions
- Paratek Pharmaceuticals (United States) (US)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s12936-025-05448-w
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- U.S. Department of Defense
- U.S. Department of Energy
- Oak Ridge Associated Universities
- Oak Ridge Institute for Science and Education
- Walter Reed Army Institute of Research