Solventless Catalytic C–H and C–X Functionalization without Ball Milling
A low-cost, operationally simple approach to eight different solventless Rh-, Ru-, Ir-, and Pd-catalyzed C-H and C-X functionalizations, as well as the synthesis of difficult-to-make rhodacyclic complexes, is presented. The method uses open-air grinding and heating, is reproducible, gives competitive yields compared with automated ball milling protocols, and can be extended to the late-stage modification of various bioactive compounds.
Authors
- Carolina Méndez‐Gálvez (ORCID: https://orcid.org/0000-0001-7977-9595)
- Lukasz T. Pilarski (ORCID: https://orcid.org/0000-0002-9353-2238)
- Fredrik Barnå (ORCID: https://orcid.org/0009-0006-5069-2190)
- Boris Olsthoorn
- David Estébanez Rosich
- Paul J. Gates (ORCID: https://orcid.org/0000-0001-8619-7745)
Institutions
- Uppsala University (SE)
- University of Bristol (GB)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1021/acs.joc.5c00109
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Carl Tryggers Stiftelse för Vetenskaplig Forskning
- Vetenskapsrådet