<i>Piper Longum</i>’s Neuroprotective Role Against Amyloid-β and Okadaic Acid-Induced Toxicity in U87MG Cells Through the Lipocalin-2 Pathway

These findings demonstrate that <i>P. longum</i> exerts neuroprotective effects against Aβ- and tau-induced toxicity in an astrocyte cell model by alleviating the damage from Aβ and OKA that induce neuroinflammation and decreasing LCN2 levels in astrocyte cells. Additionally, there is need to investigate other underlying mechanisms for novel use of <i>P. longum</i> that may contribute to AD recovery in the future.

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Publication Details

Journal
Journal of pharmacopuncture
Published
2025-06-19
DOI
https://doi.org/10.3831/kpi.2025.28.2.92
Primary Topic
Piperaceae Chemical and Biological Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Piper Longum’s Neuroprotective Role Against Amyloid-β and Okadaic Acid-Induced Toxicity in U87MG Cells Through the Lipocalin-2 Pathway

Yunna Kim, Seung‐Hun Cho, S.‐K. Sung, S.H. Shin
Journal of pharmacopuncture
Piperaceae Chemical and Biological Studies
article

Piper Longum’s Neuroprotective Role Against Amyloid-β and Okadaic Acid-Induced Toxicity in U87MG Cells Through the Lipocalin-2 Pathway

Yunna Kim, Seung‐Hun Cho, S.‐K. Sung, S.H. Shin
article en

Abstract

These findings demonstrate that <i>P. longum</i> exerts neuroprotective effects against Aβ- and tau-induced toxicity in an astrocyte cell model by alleviating the damage from Aβ and OKA that induce neuroinflammation and decreasing LCN2 levels in astrocyte cells. Additionally, there is need to investigate other underlying mechanisms for novel use of <i>P. longum</i> that may contribute to AD recovery in the future.

Journal of pharmacopunctureVol. 28(2)
Kyung Hee University (KR), Kyung Hee University Medical Center (KR), Kyung Hee University East-West Neo Medical Center (KR)
National Research Foundation, Kyung Hee University, National Research Foundation of Korea, Ministry of Science and ICT, South Korea
Zero hunger
Openalex Percentile: Top 81%
Piperaceae Chemical and Biological Studies
DOIOpen Access PDFOpenAlex
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<i>Piper Longum</i>’s Neuroprotective Role Against Amyloid-β and Okadaic Acid-Induced Toxicity in U87MG Cells Through the Lipocalin-2 Pathway — Yunna Kim, Seung‐Hun Cho, et al. · Journal of pharmacopuncture (2025) | TGRS Research Map | TGRS