The processed Sanguisorba officinalis L. triterpenoids prevent colon cancer through the TNF-α/NF-κB signaling pathway, combined with network pharmacology, molecular simulation dynamics and experimental verification
These results suggest that TP has a more pronounced colon cancer prevention effect than TR. TP play a role in preventing colon cancer by down-regulating TNF-<i>α</i> and thereby inhibiting the NF-κB signaling pathway. This research not only fills the mechanism gap of S.L. in the field of colon cancer prevention, but also provides methodological support and theoretical foundation for its transition from traditional Chinese medicine to clinical practice through the integration of multi-disciplinary technologies and the verification of precise targets.
Authors
- Xiaotian Wu (ORCID: https://orcid.org/0000-0003-2551-1432)
- Chunli Gan (ORCID: https://orcid.org/0000-0003-2235-745X)
- Shah Syed Faizan Ali (ORCID: https://orcid.org/0000-0003-3613-0248)
- Chunjuan Yang (ORCID: https://orcid.org/0000-0001-9221-7167)
- Shuang Jiang (ORCID: https://orcid.org/0000-0002-4675-7143)
- Xiaotong Wang (ORCID: https://orcid.org/0000-0002-5417-743X)
- Zhibin Wang (ORCID: https://orcid.org/0000-0001-7441-7536)
- Zhengyang Wang (ORCID: https://orcid.org/0000-0002-4906-5708)
- Feng Zheng (ORCID: https://orcid.org/0000-0002-1130-5948)
- Xiaofeng Zhang (ORCID: https://orcid.org/0000-0003-2738-3286)
- Xuepeng Shi
- Yuanqiu Mu
Institutions
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1605326
- Citations
- 1
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81