The functional and clinical significance of nucleoporin NUP153 across human cancers: a systematic study based on multi-omics analysis and bench work validation
Our findings indicate that NUP153 is a critical factor in multiple cancers, especially gastric cancer, where its elevated expression holds promise as a diagnostic and prognostic biomarker. The results indicate that NUP153 plays a key role in modulating the immune microenvironment and driving tumour progression, positioning it as a potential target for future therapeutic interventions. However, additional studies are required to elucidate the specific molecular mechanisms underlying NUP153's function in cancer and to explore its clinical applicability.
Authors
- Yu Zhou (ORCID: https://orcid.org/0000-0002-2102-9377)
- Zhaorui Wang
- Menghui Duan
- Qiang Wu (ORCID: https://orcid.org/0000-0003-3841-3591)
- Chen Li (ORCID: https://orcid.org/0000-0003-3556-2719)
- Qing Wang (ORCID: https://orcid.org/0000-0001-6540-1858)
- Jing Huang (ORCID: https://orcid.org/0000-0002-2167-8385)
- Youfu He (ORCID: https://orcid.org/0000-0003-4926-1706)
- FengYan Wu
Institutions
- Guiyang Medical University (CN)
- Guangxi Medical University (CN)
- Henan University (CN)
- Guizhou University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- First Hospital of China Medical University (CN)
- Zhengzhou People's Hospital (CN)
- Guizhou Provincial People's Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Gaozhou People's Hospital (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1613688
- Citations
- 3
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 2.42