Serum lipidomic analysis identifies potential therapeutic targets for neurodegeneration
Circulating VLSFAs are inversely associated with the neurodegeneration biomarker NfL and positively correlated with cognitive performance. This neuroprotective association appears to be partially mediated by blood pressure regulation pathways. These findings identify VLSFAs as a potential therapeutic target, warranting further longitudinal and interventional studies to confirm their role in mitigating neurodegeneration.
Authors
- Duanbin Li
- Lumi Zhang
- Na Zhao (ORCID: https://orcid.org/0000-0001-8648-9422)
- Guoping Peng (ORCID: https://orcid.org/0000-0003-2127-2745)
Institutions
- Zhejiang Chinese Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Human Neuroscience
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fnhum.2025.1598495
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministry of Science and Technology of the People's Republic of China
- Zhejiang Chinese Medical University
- Wenzhou Municipal Science and Technology Bureau