Life’s Crucial 9 score and chronic kidney disease: insights from NHANES 2005–2018 and the mediating role of systemic inflammation and oxidative stress
Higher LC9 scores are associated with a reduced risk of CKD, with systemic inflammation and uric acid levels partially mediating this relationship. These findings highlight the importance of comprehensive lifestyle and mental health interventions in CKD prevention and management.
Authors
- Jin Yang (ORCID: https://orcid.org/0000-0003-0612-5827)
- Taotao Dong
- Pinglin He (ORCID: https://orcid.org/0000-0001-8969-2418)
- Zhengyun Ren (ORCID: https://orcid.org/0000-0001-5284-8976)
- Qiuyang Li (ORCID: https://orcid.org/0009-0005-9107-7453)
- Zili Wang (ORCID: https://orcid.org/0000-0001-9788-4559)
- Shiyuan Qin
Institutions
- Chengdu Medical College (CN)
- Chengdu University (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fmed.2025.1605931
- Citations
- 3
- Primary Topic
- Climate Change and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 3.60
Funders
- Chengdu University