Influence of Pharmacokinetic-Pharmacodynamic Failure Mechanisms on Outcomes in Biologic Therapy Sequencing in Inflammatory Bowel Disease: A Retrospective Cohort Study
PK-PD failure mechanisms do not appear to influence subsequent treatment outcomes when switching to biologics with different modes of action. Sequencing may rather rely on aspects such as efficacy, safety, and costs.
Authors
- Ruben Due Lorentsen (ORCID: https://orcid.org/0000-0002-3877-2458)
- Casper Steenholdt (ORCID: https://orcid.org/0000-0003-3898-4212)
- Jørn Brynskov
- Jon Henneberg
- Pernille Nørgaard Petersen
Institutions
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Gentofte Hospital (DK)
- Zealand University Hospital (DK)
Publication Details
- Journal
- BioDrugs
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1007/s40259-025-00730-4
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Takeda Pharmaceuticals International