Clinical Utility of Monitoring Circulating Tumor DNA Using a Targeted Next-generation Sequencing Panel in Patients with Colorectal Cancer
The detection of and an increase in <i>KRAS</i> and <i>TP53</i> VAFs were associated with poor prognosis. ddPCR-based ctDNA monitoring results were comparable to those obtained with the NGS panel. ctDNA monitoring during treatment is clinically informative in managing colorectal cancer.
Authors
- Hyoeun Shim (ORCID: https://orcid.org/0000-0002-8985-0882)
- Soobeen Heo
- Seog Yun Park (ORCID: https://orcid.org/0000-0002-5704-646X)
- Ji Yeon Baek (ORCID: https://orcid.org/0000-0002-5068-5891)
- Sung Chan Park (ORCID: https://orcid.org/0000-0003-3949-7862)
- Chang Won Hong (ORCID: https://orcid.org/0000-0003-3577-9264)
- Jiyu Sun (ORCID: https://orcid.org/0000-0002-4010-2023)
- Sun‐Young Kong (ORCID: https://orcid.org/0000-0003-0620-4058)
- Seong Hoon Kim (ORCID: https://orcid.org/0000-0001-7921-1801)
- M K Choi (ORCID: https://orcid.org/0000-0002-1749-9675)
Institutions
- National Cancer Center (KR)
Publication Details
- Journal
- Annals of Laboratory Medicine
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3343/alm.2024.0598
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Cancer Center