Local cranial radiation combined with third-generation tyrosine kinase inhibitors improve leptomeningeal metastasis disease-free survival in patients with EGFR-mutated non-small cell lung cancer and brain metastasis
LCR combined with third-generation TKIs could improve LM-DFS and decrease 2-year LM rate compared with third-generation TKIs alone. Further studies are required to ascertain this effect.
Authors
- Linbo Cai (ORCID: https://orcid.org/0000-0003-4411-4125)
- Yanying Yang (ORCID: https://orcid.org/0000-0002-6695-2069)
- Weiping Hong (ORCID: https://orcid.org/0009-0009-9856-5854)
- Xiaoyu Hua (ORCID: https://orcid.org/0009-0000-3895-2275)
- Qian Wang (ORCID: https://orcid.org/0000-0003-4755-7001)
- Juan Li (ORCID: https://orcid.org/0000-0002-8530-9001)
- Hui Wang (ORCID: https://orcid.org/0000-0001-6545-3826)
- Junjie Zhen
- Mingyao Lai (ORCID: https://orcid.org/0009-0009-4564-1139)
- Shoaib Bashir
Institutions
- First Affiliated Hospital of Jinan University (CN)
- Guangdong 999 Brain Hospital (CN)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1007/s11060-025-05045-6
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00