Comparative effectiveness of second‐line treatments for epileptic spasms
This updated analysis with an expanded sample size provided power for additional subgroup analysis. Overall response rates were low, and at best only one third had remission after second treatment. Results support a clinical strategy of switching mechanism of action when selecting a second medication for epileptic spasms (i.e., use vigabatrin after hormonal therapy, or hormonal therapy after vigabatrin). Our findings also support the use of standard over nonstandard therapies.
Authors
- Zachary M. Grinspan (ORCID: https://orcid.org/0000-0001-6705-0932)
- Renée A. Shellhaas (ORCID: https://orcid.org/0000-0002-3175-3908)
- John R. Mytinger (ORCID: https://orcid.org/0000-0001-7901-3960)
- Ignacio Valencia (ORCID: https://orcid.org/0000-0003-2385-4933)
- Jason Coryell (ORCID: https://orcid.org/0000-0002-1442-5259)
- Shaun A. Hussain (ORCID: https://orcid.org/0000-0001-6947-8852)
- Elissa Yozawitz (ORCID: https://orcid.org/0000-0001-8230-8364)
- Kelly G. Knupp (ORCID: https://orcid.org/0000-0002-1967-0827)
- Wendy G. Mitchell (ORCID: https://orcid.org/0000-0001-8082-1383)
- William D. Gaillard (ORCID: https://orcid.org/0000-0001-5709-0033)
- Anne T. Berg (ORCID: https://orcid.org/0000-0002-0298-5523)
- Courtney J. Wusthoff (ORCID: https://orcid.org/0000-0002-1882-5567)
- Tobias Loddenkemper (ORCID: https://orcid.org/0000-0003-2074-0674)
- Cynthia Keator
- Anup D. Patel
- Catherine J. Chu (ORCID: https://orcid.org/0000-0001-7670-9313)
- Iván Sánchez Fernández (ORCID: https://orcid.org/0000-0002-4313-002X)
- Nilika S. Singhal (ORCID: https://orcid.org/0000-0002-9323-3000)
- Elaine C. Wirrell (ORCID: https://orcid.org/0000-0003-3015-8282)
- Kristen Barbour (ORCID: https://orcid.org/0000-0003-0293-0108)
- Douglas R. Nordli (ORCID: https://orcid.org/0000-0002-1617-0667)
- Chellamani Harini (ORCID: https://orcid.org/0000-0002-1452-5065)
Institutions
- Boston Children's Hospital (US)
- Albert Einstein College of Medicine (US)
- Nationwide Children's Hospital (US)
- Mayo Clinic (US)
- Children's National (US)
- Children's Hospital of Los Angeles (US)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Epilepsy Foundation (US)
- WinnMed (US)
- University of California San Diego (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Cook Children's Medical Center (US)
- Children's Hospital Colorado (US)
- Children's Hospital at Montefiore (US)
- Boston Children's Museum (US)
- Weill Cornell Medicine (US)
- Drexel University (US)
- University of California, Davis (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1111/epi.18511
- Citations
- 3
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- American Epilepsy Society
- Pediatric Epilepsy Research Foundation
- Epilepsiatutkimussäätiö
- Epilepsy Society