Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23/JAK2/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat syndrome
Systemic pathophysiological alterations were observed in rats with damp-heat syndrome. The comprehensive protective effects of DYY involved suppression of neutrophil extracellular traps (NETs) formation through downregulation of PADI4 expression, modulation of inflammatory responses, inhibition of the IL-23/JAK2/STAT3 signaling pathway, restoration of intestinal microecological balance and metabolic homeostasis, and enhancement of antioxidant.
Authors
- Jianzhong Yu (ORCID: https://orcid.org/0000-0002-4883-646X)
- Xihua Chen (ORCID: https://orcid.org/0000-0002-8331-5459)
- Xiaogang Jiang (ORCID: https://orcid.org/0000-0001-9719-9711)
- Zhenyu Xuan (ORCID: https://orcid.org/0000-0001-9344-8493)
- Yunsheng Yang (ORCID: https://orcid.org/0000-0003-0361-7674)
- Jinghua Yu (ORCID: https://orcid.org/0000-0001-5043-0322)
- Qi Wang (ORCID: https://orcid.org/0000-0002-9082-1675)
- Lengqiu Guo
- Song Zhu
- Wei Peng
- Lan Wei
- Chunyan Min
- Jian Zhang (ORCID: https://orcid.org/0000-0002-4372-2826)
- Hongbo Zhao (ORCID: https://orcid.org/0000-0002-7523-9134)
Institutions
- Target (United States) (US)
- Soochow University (TW)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Suzhou Research Institute (CN)
- Suzhou Vocational Health College (CN)
- Hainan Provincial Hospital of Traditional Chinese Medicine (CN)
- Shaanxi Normal University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1080/07853890.2025.2519684
- Citations
- 2
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.59