Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals
FASN in POMC neurons plays an age- and neuron-specific role in regulating feeding, energy expenditure, and glucose homeostasis through mechanisms including the sympathetic nervous system. These findings highlight FASN as a potential therapeutic target for metabolic diseases by improving energy expenditure and insulinemia. Given the developmental programming of metabolic outcomes, interventions aimed at modulating FASN activity may have long-lasting benefits in managing metabolic diseases.
Authors
- Bandy Chen (ORCID: https://orcid.org/0009-0009-9099-1218)
- Syann Lee
- Chen Liu (ORCID: https://orcid.org/0000-0002-5922-0951)
- Joel K. Elmquist (ORCID: https://orcid.org/0000-0001-6929-6370)
- Yanbin Dong (ORCID: https://orcid.org/0000-0001-7848-7160)
- Luis Leon‐Mercado (ORCID: https://orcid.org/0000-0001-6362-7968)
- Arely Tinajero
- Caleb C. Lord
Institutions
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/j.molmet.2025.102177
- Citations
- 1
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Fondation Leducq
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases