Single-Nucleus RNA-Sequencing Identifies a Differential Profibrotic Response in Parietal Epithelial Cells in Primary Versus Maladaptive Focal Segmental Glomerulosclerosis
This study presents a single-cell transcriptional landscape of well-phenotyped patients with FSGS and provides evidence for a differential profibrotic PEC response in primary versus maladaptive FSGS.
Authors
- Björn Meijers (ORCID: https://orcid.org/0000-0002-2846-2026)
- Ben Sprangers (ORCID: https://orcid.org/0000-0003-1314-9675)
- Tom Venken (ORCID: https://orcid.org/0000-0003-0773-1810)
- Thomas Van Brussel (ORCID: https://orcid.org/0000-0002-1706-8381)
- Amaryllis H. Van Craenenbroeck (ORCID: https://orcid.org/0000-0003-4728-9406)
- Diether Lambrechts
- Rogier Schepers
- ضرغام جاسم محمد النعيمي (ORCID: https://orcid.org/0000-0002-8285-6624)
Institutions
- Ziekenhuis Oost-Limburg (BE)
- Hasselt University (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/j.ekir.2025.06.023
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering