Association of antibody and T cell receptor repertoires in Trypanosoma cruzi infected rhesus macaques and host response to infection
Chronic T. cruzi infection is associated with strong alterations in Ig and TCR repertoires in rhesus macaques, but these repertoires are minimally affected by parasite diversity and host responses to infection. A better understanding of these processes could help develop new immunotherapies against T. cruzi infection.
Authors
- Eric Dumonteil (ORCID: https://orcid.org/0000-0001-9376-0209)
- Weihong Tu
- Claudia Herrera (ORCID: https://orcid.org/0000-0002-9009-4201)
- Kelly Goff (ORCID: https://orcid.org/0000-0003-2682-6532)
- Preston A. Marx (ORCID: https://orcid.org/0000-0002-6955-2511)
- Rachel Clear
Institutions
- Tulane University (US)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1186/s12929-025-01152-8
- Citations
- 3
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Center for Research Resources
- Office of Research Infrastructure Programs, National Institutes of Health