A Novel Capillary Zone Electrophoresis Technique for Pharmacokinetic Studies on Porphyrin-C<sub>60</sub> Based Neuroprotectors. Preliminary Report
A novel, fast-n-reliable, Quartz capillary silica zone electrophoresis required to upgrade an arsenal of analytical tools for current pharmacokinetics studies on porphyrin-fullerene nanoparticles has been proposed. The fullerene(C60)-tetra(p-hydroxyphenyl)porphyrin structures, known for their capabilities to paramagnetic 25Mg2+ delivery, were found quantitatively detectable in a total rat brain cytosol (S125) fraction, once these nanocationites administered in a single, either 1.0 mg/kg or 20.0 mg/kg, i.v. injection followed by 12 hrs long animal-drug exposition time. Driven by pressing needs in ongoing preclinical trial platform developments, the CZE track proposed might make an impact on both convenience and efficiency of pharmacokinetic estimate of medicinal nanocationites.
Authors
- Dmitry Kuznetsov (ORCID: https://orcid.org/0000-0002-9972-947X)
- A. S. Semenova (ORCID: https://orcid.org/0000-0001-6932-9566)
- O. V. Kamkina
- Alexander A. Bukhvostov (ORCID: https://orcid.org/0000-0002-1488-6290)
- Stanislav Arkhangelskiy
Institutions
- Pirogov Russian National Research Medical University (RU)
Publication Details
- Journal
- Pharmacology & Pharmacy
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4236/pp.2025.166011
- Primary Topic
- Porphyrin and Phthalocyanine Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Higher Education of the Russian Federation