Maternal intestinal L. vaginalis facilitates embryo implantation and survival through enhancing uterine receptivity in sows
Overall, intestinal microbial-host interactions can occur during early pregnancy and may be contribute to maternal metabolic changes and influence pregnancy outcomes in mammals. Our study provides insights of maternal intestinal L. vaginalis to enhance uterine receptivity and to benefit embryo/fetal survival through a gut-uterus axis, contributing to advanced concept and novel strategy to manipulate gut microbiota during early pregnancy, and in turn to improve embryo implantation and reduce embryo loss in sows. Video Abstract.
Authors
- Yifan Hu (ORCID: https://orcid.org/0000-0002-7980-6626)
- Haoyi Jiang (ORCID: https://orcid.org/0009-0007-7841-1132)
- Xianghua Yan (ORCID: https://orcid.org/0000-0003-2238-6218)
- Qianhong Ye (ORCID: https://orcid.org/0009-0002-7826-5458)
- Libao Ma (ORCID: https://orcid.org/0000-0001-6806-6899)
- Yuwen Chen (ORCID: https://orcid.org/0000-0003-1804-4653)
- Jiaying Chen (ORCID: https://orcid.org/0000-0003-4297-1545)
- Ziyi He
- Longshan Han
- Tingting Luo
Institutions
- Huazhong Agricultural University (CN)
- Center of Hubei Cooperative Innovation for Emissions Trading System (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1186/s40168-025-02141-7
- Citations
- 4
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China