The Music for Subanesthetic Infusions of Ketamine randomised clinical trial: ketamine as a psychedelic treatment for highly refractory depression
This trial found large and notably sustained benefits of ketamine-psychotherapy for severe TRD, with or without music, and psychedelic experiences of comparable intensity to those observed with psilocybin. Mystical-like experiences may particularly contribute to ketamine's immediate and persistent psychiatric benefits.
Authors
- Gustavo Turecki (ORCID: https://orcid.org/0000-0003-4075-2736)
- Karl Looper (ORCID: https://orcid.org/0000-0003-4258-3286)
- Mendel Kaelen (ORCID: https://orcid.org/0000-0002-6987-9346)
- Lê-Anh Dinh-Williams (ORCID: https://orcid.org/0000-0002-5486-7756)
- Vincent Dagenais‐Beaulé (ORCID: https://orcid.org/0000-0002-8526-857X)
- Soham Rej (ORCID: https://orcid.org/0000-0002-3908-9124)
- David Erritzøe (ORCID: https://orcid.org/0000-0002-7022-6211)
- Sara de la Salle (ORCID: https://orcid.org/0000-0002-1698-5938)
- Stéphane Richard‐Devantoy (ORCID: https://orcid.org/0000-0003-1211-960X)
- Julien Thibault Lévesque (ORCID: https://orcid.org/0000-0003-1438-6680)
- Nicolas Garel (ORCID: https://orcid.org/0000-0002-4031-9943)
- Kyle T. Greenway (ORCID: https://orcid.org/0000-0002-7829-493X)
Institutions
- Queen's University Belfast (GB)
- Douglas Mental Health University Institute (CA)
- Jewish General Hospital (CA)
- National Confidential Enquiry into Patient Outcome and Death (GB)
- Stanford Medicine (US)
- Imperial College London (GB)
- McGill University (CA)
- Stanford University (US)
Publication Details
- Journal
- The British Journal of Psychiatry
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1192/bjp.2025.102
- Citations
- 5
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 11.53
Funders
- Jewish General Hospital