Reproductive and developmental safety assessment of Ashwagandha (Withania somnifera) root extract in Wistar rats
The parameters such as T4 and TSH levels, body weight, and weight of reproductive organs in adult Wistar rats and pups, were within range even at the maximum dosage. No evidence of toxicity at various stages of development and reproduction with aqueous extract was observed when administered orally. Rats' ability to reproduce and develop was unaffected by standardized ashwagandha root extract.
Authors
- V. Gayathri (ORCID: https://orcid.org/0000-0001-9764-0140)
- Periyathambi Kalaivani
- Karuppasamy Kalaiselvan
- Shonam Tamrakar
- Siva Ramamoorthy (ORCID: https://orcid.org/0000-0001-7509-8602)
- V Sweatha
Institutions
- Sri Ramachandra Institute of Higher Education and Research (IN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fphar.2025.1572025
- Citations
- 3
- Primary Topic
- Phytochemicals and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 7.14