UV Irradiation’s Influence on Fumitory Extract-Loaded Liposomes

The aim of the present study was the characterization of fumitory extract-loaded liposomal vesicles after UV irradiation <i>via</i> the determination of the encapsulation efficiency, size, polydispersity index (PDI), zeta potential, mobility, and conductivity. The encapsulation efficiency was the same before and after UV irradiation (>69%). The particle size and PDI of the UV-irradiated liposomes with the fumitory extract were 294.2 ± 4.1 nm and 0.387 ± 0.011, respectively. The zeta potential after UV irradiation was −5.51 ± 0.4 mV. The mobility and conductivity of the obtained liposomal particles were −0.429 ± 0.012 µmcm/Vs and 0.468 ± 0.005 mS/cm, respectively. The results indicate the existence of nanoparticles and a non-uniform system, while a negative zeta potential value is related to the organization of phospholipids. Since UV irradiation did not cause significant changes in all of the mentioned parameters of the fumitory extract-loaded liposomes, it can be employed as a sterilization step in the preparation of liposomes.