Bolus doses of insulin versus a continuous insulin infusion for treating hyperkalaemia in adults: A case series

Hyperkalaemia is a medical emergency that may manifest with a spectrum of cardiac conduction abnormalities and, if not promptly managed, can progress to cardiac arrest. While standard management typically involves stat doses of insulin to lower serum potassium, the optimal dosing regimen remains controversial. Patients whose serum potassium exceeds the upper normal limit by more than 1 mmol/L often require repeated conventional management to shift potassium intracellularly - usually every 2 to 4 h. Although dialysis is indicated in patients with concomitant renal dysfunction, its availability in resource-constrained settings is limited. We present three cases of symptomatic hyperkalaemia successfully managed with continuous insulin infusions, thereby obviating the need for dialysis. These cases underscore the potential role of continuous insulin infusions as an alternative strategy for correcting hyperkalaemia in settings where dialysis is not immediately available.

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Journal
SAGE Open Medical Case Reports
Published
2025-06-18
DOI
https://doi.org/10.1177/2050313x251348368
Primary Topic
Potassium and Related Disorders
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article
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article

Bolus doses of insulin versus a continuous insulin infusion for treating hyperkalaemia in adults: A case series

Neil Alexander Martinson, Ebrahim Variava, Nicole King, Mmakwata Lesudi
SAGE Open Medical Case Reports
Potassium and Related Disorders
article

Bolus doses of insulin versus a continuous insulin infusion for treating hyperkalaemia in adults: A case series

Neil Alexander Martinson, Ebrahim Variava, Nicole King, Mmakwata Lesudi
article en

Abstract

Hyperkalaemia is a medical emergency that may manifest with a spectrum of cardiac conduction abnormalities and, if not promptly managed, can progress to cardiac arrest. While standard management typically involves stat doses of insulin to lower serum potassium, the optimal dosing regimen remains controversial. Patients whose serum potassium exceeds the upper normal limit by more than 1 mmol/L often require repeated conventional management to shift potassium intracellularly - usually every 2 to 4 h. Although dialysis is indicated in patients with concomitant renal dysfunction, its availability in resource-constrained settings is limited. We present three cases of symptomatic hyperkalaemia successfully managed with continuous insulin infusions, thereby obviating the need for dialysis. These cases underscore the potential role of continuous insulin infusions as an alternative strategy for correcting hyperkalaemia in settings where dialysis is not immediately available.

SAGE Open Medical Case ReportsVol. 13
Johns Hopkins University (US), University of the Witwatersrand (ZA), Johns Hopkins Medicine (US), Perinatal HIV Research Unit (ZA)
Openalex Percentile: Top 77%
Potassium and Related Disorders
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Bolus doses of insulin versus a continuous insulin infusion for treating hyperkalaemia in adults: A case series — Neil Alexander Martinson, Ebrahim Variava, et al. · SAGE Open Medical Case Reports (2025) | TGRS Research Map | TGRS