A novel short-course, low-intensity blood-flow-restricted exercise (BFRE) regimen to study satellite cell function in critical illness survivors with sustained muscle atrophy following intensive care unit-acquired weakness (ICUAW)
This study demonstrates that training with a novel short-duration, low-intensity BFRE regimen results in higher satellite cell content in healthy muscle and can be completed by ICUAW survivors. Pilot data suggest that sustained satellite cell dysfunction may impede muscle mass reconstitution after ICU discharge.
Authors
- Jane Batt (ORCID: https://orcid.org/0000-0001-7015-189X)
- Caterina Di Ciano‐Oliveira
- Sunita Mathur (ORCID: https://orcid.org/0000-0001-5564-9796)
- Pamela Plant (ORCID: https://orcid.org/0000-0002-3781-4337)
- Christina Doherty
- Manoela de Paula Ferreira (ORCID: https://orcid.org/0000-0003-3446-7752)
- Judy Correa (ORCID: https://orcid.org/0009-0002-6380-6856)
- Christian Martin (ORCID: https://orcid.org/0009-0004-1679-1908)
- Nathalia Parente de Sousa Maia
Institutions
- University of Toronto (CA)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fphys.2025.1553471
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research
- Temerty Faculty of Medicine, University of Toronto