The Mutational Status of Driver Genes in Patients With Resected Pancreatic Ductal Adenocarcinoma Is Associated With Pathological Characteristics and Overall Survival
In patients with resected PDAC, KRAS -wt, and TP53 -wt were associated with improved pathological characteristics and mOS, regardless of neoadjuvant therapy. The co-occurrence of 2 or more driver gene mutations was associated with worse mOS.
Authors
- Marco Dal Molin (ORCID: https://orcid.org/0000-0003-1581-3576)
- Amanda L. Blackford (ORCID: https://orcid.org/0000-0002-6519-4833)
- Julia Purchla
- Kelly J. Lafaro (ORCID: https://orcid.org/0000-0002-7070-7269)
- Thomas McPhaul
- Swathikan Chidambaram (ORCID: https://orcid.org/0000-0002-4009-3243)
- William R. Burns (ORCID: https://orcid.org/0000-0002-7634-9730)
- Brady A. Campbell (ORCID: https://orcid.org/0000-0002-0792-6928)
- Christopher R. Shubert (ORCID: https://orcid.org/0000-0001-6472-2350)
- Jin Peng He (ORCID: https://orcid.org/0000-0001-9149-2247)
- Richard A. Burkhart (ORCID: https://orcid.org/0000-0002-1618-4006)
- John L. Cameron
- Ming-Tseh Lin
- Ralph H. Hruban
- Dario Solinas
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Cancer Research Center (US)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1097/sla.0000000000006794
- Citations
- 4
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 4.18