AAV-HBV mouse model replicates the intrahepatic immune landscape of chronic HBV patients at single-cell level
Long term high titer AAV-HBV mouse liver transduction led to T-cell exhaustion, as evidenced by expression of conventional immune checkpoint markers at mRNA and protein levels. In both IT and IA donors, a similar CD8 exhausted T-cell population was identified, with increased frequency observed in IA donors. These data support the use of the AAV-HBV mouse model to study classical T-cell exhaustion in HBV infection and the effect of immune-based therapeutic interventions.
Authors
- Wim Pierson (ORCID: https://orcid.org/0000-0003-1369-4606)
- George Kukolj
- Nádia Conceição‐Neto (ORCID: https://orcid.org/0000-0002-9659-6835)
- Liese Aerts (ORCID: https://orcid.org/0009-0001-1190-9653)
- Ondřej Podlaha
- Dries De Maeyer (ORCID: https://orcid.org/0000-0002-1314-3348)
- Koen Dockx
- Ellen Van Gulck (ORCID: https://orcid.org/0009-0008-3343-0644)
- Zhiyuan Yao (ORCID: https://orcid.org/0000-0002-5759-9822)
- Matthias Beyens (ORCID: https://orcid.org/0000-0003-3304-0706)
- Vinod Krishna (ORCID: https://orcid.org/0000-0003-1568-5295)
- Koen Van Den Berge (ORCID: https://orcid.org/0000-0003-2214-0947)
- Isabel Nájera
- Qun Wu (ORCID: https://orcid.org/0000-0001-6456-3855)
- Chris Li (ORCID: https://orcid.org/0000-0002-9350-2039)
- Qinglin Han
- Ren Zhu
Institutions
- Johnson & Johnson (United States) (US)
- Charles River Laboratories (Netherlands) (NL)
- Charles River Laboratories (United States) (US)
- Johnson & Johnson (Brazil) (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1421712
- Citations
- 3
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06