Arterial, Venous, and Cerebrospinal Fluid Flow and Pulsatility in Stroke-Related Cerebral Small Vessel Disease: A Longitudinal Analysis
Associations between vascular/CSF pulsatility, cerebral blood flow, WMH/PVS, and clinical SVD features are complex. The lack of association between intracranial arterial, venous, or CSF pulsatility, cerebral blood flow, and WMH or PVS longitudinal change in this large, covariate-adjusted analysis questions the presumption that high intracranial vascular pulsatility causes SVD and its progression, consistent with other recent longitudinal studies. Intracranial pulsatility may differ from systemic vascular measures in their cause-pathogenic role(s) in SVD and should be considered separately.
Authors
- Joanna Marguerite Wardlaw (ORCID: https://orcid.org/0000-0002-9812-6642)
- Rosalind Brown (ORCID: https://orcid.org/0000-0002-7688-4864)
- Angela C.C. Jochems (ORCID: https://orcid.org/0000-0001-7392-3066)
- Fergus Doubal (ORCID: https://orcid.org/0000-0002-2769-3148)
- Yajun Cheng (ORCID: https://orcid.org/0000-0002-5227-9811)
- Maria del Carmen Valdés Hernández (ORCID: https://orcid.org/0000-0003-2771-6546)
- I. Howard Marshall (ORCID: https://orcid.org/0000-0001-7778-4331)
- Lucia Ballerini (ORCID: https://orcid.org/0000-0002-1956-4012)
- Michael J. Thrippleton (ORCID: https://orcid.org/0000-0001-7858-9917)
- Úna Clancy (ORCID: https://orcid.org/0000-0002-8062-7537)
- Eleni Sakka (ORCID: https://orcid.org/0000-0002-7082-1168)
- Dominic Job (ORCID: https://orcid.org/0000-0002-7829-7217)
- Daniela Jaime García (ORCID: https://orcid.org/0000-0002-9457-9855)
- Francesca M. Chappell (ORCID: https://orcid.org/0000-0002-7742-1757)
- Carmen Arteaga (ORCID: https://orcid.org/0000-0003-2424-7123)
- Cameron Manning
- Alasdair G. Morgan (ORCID: https://orcid.org/0000-0001-9470-740X)
- Stewart Wiseman (ORCID: https://orcid.org/0000-0001-6739-5797)
- Emilie Sleight (ORCID: https://orcid.org/0000-0003-0034-4578)
- Michael Stringer (ORCID: https://orcid.org/0000-0002-3811-4439)
- Roberto Duarte Coello (ORCID: https://orcid.org/0000-0003-2952-2163)
- Junfang Zhang (ORCID: https://orcid.org/0000-0001-5969-4789)
- Xiaodi Liu
Institutions
- Shanghai Jiao Tong University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- MRC Centre for Reproductive Health (GB)
- Maine Farmland Trust (US)
- University of Hong Kong (HK)
- University for Foreigners Perugia (IT)
Publication Details
- Journal
- Stroke
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1161/strokeaha.124.049103
- Citations
- 2
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.04