Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations
A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Yann Le Guen (ORCID: https://orcid.org/0000-0001-6649-8364)
- Gonzálo Arboleda (ORCID: https://orcid.org/0000-0003-1781-939X)
- Victoria C. Merritt (ORCID: https://orcid.org/0000-0001-5683-4168)
- Norikazu Hara (ORCID: https://orcid.org/0000-0001-8525-3469)
- Paolo Caffarra (ORCID: https://orcid.org/0000-0003-2246-5223)
- Anita L. DeStefano (ORCID: https://orcid.org/0000-0002-9335-2819)
- Ellen M. Wijsman (ORCID: https://orcid.org/0000-0002-2725-6669)
- Laura Molina‐Porcel (ORCID: https://orcid.org/0000-0003-4068-8578)
- Jean‐Charles Lambert (ORCID: https://orcid.org/0000-0003-0829-7817)
- Martin Ingelsson (ORCID: https://orcid.org/0000-0001-5466-8370)
- John Cornelis Van Swieten (ORCID: https://orcid.org/0000-0001-6278-6844)
- Aad van der Lugt (ORCID: https://orcid.org/0000-0002-6159-2228)
- Maëlenn Guerchet (ORCID: https://orcid.org/0000-0002-0470-5556)
- Katrine Laura Rasmussen (ORCID: https://orcid.org/0009-0000-1093-9415)
- Geir Selbæk (ORCID: https://orcid.org/0000-0001-6511-8219)
- Jens Wiltfang (ORCID: https://orcid.org/0000-0003-1492-5330)
- Clifton L. Dalgard (ORCID: https://orcid.org/0000-0003-2025-8239)
- Luís Miguel Real (ORCID: https://orcid.org/0000-0003-4932-7429)
- Lorenzo Campanelli
- Bernardo de Mattos Viana (ORCID: https://orcid.org/0000-0001-8792-2996)
- Olivier Hanon (ORCID: https://orcid.org/0000-0002-4697-122X)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Caroline Graff (ORCID: https://orcid.org/0000-0002-9949-2951)
- Jurgen A.H.R. Claassen (ORCID: https://orcid.org/0000-0002-1778-8151)
- Giacomina Rossi (ORCID: https://orcid.org/0000-0001-6680-2725)
- María F. Mahecha (ORCID: https://orcid.org/0000-0002-2306-5216)
- Patricia Solís (ORCID: https://orcid.org/0000-0002-1058-5677)
- Agustı́n Ruiz (ORCID: https://orcid.org/0000-0003-2633-2495)
- Bébène Bandzouzi
- Monica Goss
- Kristel Sleegers (ORCID: https://orcid.org/0000-0002-0283-2332)
- Rafael Aránguiz (ORCID: https://orcid.org/0000-0002-0638-7344)
- Cornelia M. van Duijn (ORCID: https://orcid.org/0000-0002-2374-9204)
- Patrizia Mecocci (ORCID: https://orcid.org/0000-0003-0729-5246)
- Pablo Mir (ORCID: https://orcid.org/0000-0003-1656-302X)
- Silvia Kochen (ORCID: https://orcid.org/0000-0003-0513-3534)
- Oliver Peters (ORCID: https://orcid.org/0000-0003-0568-2998)
- Lucilla Parnetti (ORCID: https://orcid.org/0000-0001-5722-3967)
- Paulina Orellana (ORCID: https://orcid.org/0000-0001-8752-7750)
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-4461-3568)
- Vilmantas Giedraitis (ORCID: https://orcid.org/0000-0003-3423-2021)
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Xiaopu Zhou (ORCID: https://orcid.org/0000-0001-5307-5805)
- Shahram Bahrami (ORCID: https://orcid.org/0000-0002-8179-2788)
- Julius Popp (ORCID: https://orcid.org/0000-0002-0068-0312)
- Takeshi Ikeuchi (ORCID: https://orcid.org/0000-0001-8828-8085)
- Mark W. Logue (ORCID: https://orcid.org/0000-0001-9347-7892)
- Eloy Rodríguez‐Rodríguez (ORCID: https://orcid.org/0000-0001-7742-677X)
- Philip Scheltens (ORCID: https://orcid.org/0000-0002-1046-6408)
- Laura Morelli (ORCID: https://orcid.org/0000-0001-5759-1807)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- David Wallon (ORCID: https://orcid.org/0000-0002-2634-7198)
- Norbert Scherbaum (ORCID: https://orcid.org/0000-0003-1759-6990)
- Itziar de Rojas (ORCID: https://orcid.org/0000-0002-2148-381X)
- Kun Ho Lee (ORCID: https://orcid.org/0000-0003-4144-8162)
- Patrick G. Kehoe (ORCID: https://orcid.org/0000-0002-7542-1139)
- Valentina Escott‐Price (ORCID: https://orcid.org/0000-0003-1784-5483)
- Pau Pástor (ORCID: https://orcid.org/0000-0002-7493-8777)
- Jenny Ortega-Rojas
- Karen A. Mather (ORCID: https://orcid.org/0000-0003-4143-8941)
- Natividad Olivar (ORCID: https://orcid.org/0000-0003-4598-6865)
- Daniel Gustavo Politis (ORCID: https://orcid.org/0000-0002-9964-0272)
- Bárbara Ángel (ORCID: https://orcid.org/0000-0001-8773-5904)
- Alfredo Ramı́rez (ORCID: https://orcid.org/0000-0003-4991-763X)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Teresa Juárez‐Cedillo (ORCID: https://orcid.org/0000-0002-9442-3471)
- Hampton L. Leonard (ORCID: https://orcid.org/0000-0003-2390-8110)
- Philippe Amouyel (ORCID: https://orcid.org/0000-0001-9088-234X)
- Luis Ignacio Brusco
- Yuk Yee Leung (ORCID: https://orcid.org/0000-0002-3047-5440)
- Fanny C.F. Ip (ORCID: https://orcid.org/0000-0001-5162-1761)
- José Luís Royo (ORCID: https://orcid.org/0000-0003-2024-4363)
- Vera Fominykh (ORCID: https://orcid.org/0000-0001-5490-2390)
- Nancy Y. Ip (ORCID: https://orcid.org/0000-0002-2763-8907)
- Patricio Fuentes (ORCID: https://orcid.org/0000-0003-0278-3494)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Cecilia Albala (ORCID: https://orcid.org/0000-0002-6135-334X)
- Alexandre de Mendonça (ORCID: https://orcid.org/0000-0002-0488-1453)
- Humberto Arboleda (ORCID: https://orcid.org/0000-0003-4148-0867)
- María Victoria Chacón
- Victoria Álvarez (ORCID: https://orcid.org/0000-0002-1916-2523)
- Carlos C Cruchaga (ORCID: https://orcid.org/0000-0002-0276-2899)
- Rebecca Sims (ORCID: https://orcid.org/0000-0002-3885-1199)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Mike A. Nalls (ORCID: https://orcid.org/0000-0003-0319-4325)
- Y T Kim (ORCID: https://orcid.org/0009-0008-0913-006X)
- Dan Rujescu (ORCID: https://orcid.org/0000-0002-1432-313X)
- Gerard Piñol‐Ripoll (ORCID: https://orcid.org/0000-0002-4495-2113)
- Lucrezia Hausner (ORCID: https://orcid.org/0000-0001-9009-2356)
- Christian González‐Billault (ORCID: https://orcid.org/0000-0003-0335-1482)
- Edgar Nunes de Moraes (ORCID: https://orcid.org/0000-0002-8923-1029)
- Raquel Sánchez‐Valle (ORCID: https://orcid.org/0000-0001-7750-896X)
- Henne Holstege (ORCID: https://orcid.org/0000-0002-7688-3087)
- Pierre‐Marie Preux (ORCID: https://orcid.org/0000-0002-2171-2977)
- Harro Seelaar (ORCID: https://orcid.org/0000-0003-1989-7527)
- Jean‐François Deleuze (ORCID: https://orcid.org/0000-0002-5358-4463)
- Maria Aparecida Camargos Bicalho (ORCID: https://orcid.org/0000-0001-6298-9377)
- Marco Túlio Gualberto Cintra (ORCID: https://orcid.org/0000-0003-3089-655X)
- José María García‐Alberca (ORCID: https://orcid.org/0000-0003-2951-6644)
- Carlo Masullo (ORCID: https://orcid.org/0000-0001-7798-3410)
- Julie Williams (ORCID: https://orcid.org/0000-0002-4069-0259)
- Lotfi Cherni (ORCID: https://orcid.org/0000-0002-7050-6539)
- Merçé Boada (ORCID: https://orcid.org/0000-0003-2617-3009)
- Richard L. Hauger (ORCID: https://orcid.org/0000-0003-1509-1868)
- Kouichi Ozaki (ORCID: https://orcid.org/0000-0003-0028-1570)
- Davide Seripa (ORCID: https://orcid.org/0000-0001-7331-0470)
- Alessio Squassina (ORCID: https://orcid.org/0000-0001-7415-7607)
- Frans R.J. Verhey (ORCID: https://orcid.org/0000-0002-8307-8406)
- Stefanie Heilmann‐Heimbach (ORCID: https://orcid.org/0000-0003-1057-465X)
- Bernard Fongang (ORCID: https://orcid.org/0000-0002-8161-1553)
- Inez H.G.B. Ramakers (ORCID: https://orcid.org/0000-0002-4747-2879)
- Fahri Küçükali (ORCID: https://orcid.org/0000-0002-3835-9639)
- Sven J. van der Lee (ORCID: https://orcid.org/0000-0003-1606-8643)
- María J. Bullido (ORCID: https://orcid.org/0000-0002-6477-1117)
- Pascal M'Belesso
- Jesper Qvist Thomassen (ORCID: https://orcid.org/0000-0003-3484-9531)
- Carole Dufouil (ORCID: https://orcid.org/0000-0003-2442-4476)
- Benedetta Nacmias (ORCID: https://orcid.org/0000-0001-9338-9040)
- Amy K.Y. Fu (ORCID: https://orcid.org/0000-0003-4085-6201)
- Martin Dichgans (ORCID: https://orcid.org/0000-0002-0654-387X)
- Jennifer S. Yokoyama (ORCID: https://orcid.org/0000-0001-7274-2634)
- Sergio Gloger (ORCID: https://orcid.org/0000-0002-8674-1306)
- Carolina Muchnik
- Magda Tsolaki (ORCID: https://orcid.org/0000-0002-2072-8010)
- Pascual Sánchez‐Juan (ORCID: https://orcid.org/0000-0002-6081-8037)
- Jürgen Deckert
- Martin Vyhnálek (ORCID: https://orcid.org/0000-0002-5976-4932)
- Lucio Tremolizzo (ORCID: https://orcid.org/0000-0003-0473-6560)
- Frank Jessen (ORCID: https://orcid.org/0000-0003-1067-2102)
- Andrea Slachevsky (ORCID: https://orcid.org/0000-0001-6285-3189)
- Anne Boland (ORCID: https://orcid.org/0000-0001-8789-5676)
- Goran Papenberg (ORCID: https://orcid.org/0000-0003-0279-1988)
- Steffi Gerlinde Riedel-Heller (ORCID: https://orcid.org/0000-0003-4321-6090)
- Céline Bellenguez (ORCID: https://orcid.org/0000-0002-1240-7874)
- Roberta Ghidoni (ORCID: https://orcid.org/0000-0002-7691-1957)
- Margaret A. Pericak‐Vance (ORCID: https://orcid.org/0000-0001-7283-8804)
- Sami Heikkinen (ORCID: https://orcid.org/0000-0002-6083-2402)
- Jordi Pérez‐Tur (ORCID: https://orcid.org/0000-0002-9111-1712)
- Atahualpa Castillo-Morales (ORCID: https://orcid.org/0000-0001-9733-6923)
- Mikko Hiltunen (ORCID: https://orcid.org/0009-0000-3553-5089)
- Masataka Kikuchi (ORCID: https://orcid.org/0000-0002-9562-841X)
- Edna Grünblatt (ORCID: https://orcid.org/0000-0001-8505-7265)
- Michael D. Greicius (ORCID: https://orcid.org/0000-0002-5462-9037)
- Matthew S. Panizzon (ORCID: https://orcid.org/0000-0002-6449-2097)
- Beatrice Arosio (ORCID: https://orcid.org/0000-0002-0615-3580)
- Anja Schneider (ORCID: https://orcid.org/0000-0001-9540-8700)
- Carolina Dalmasso (ORCID: https://orcid.org/0000-0002-4901-9955)
- Stéphanie Debette (ORCID: https://orcid.org/0000-0001-8675-7968)
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Richard Sherva (ORCID: https://orcid.org/0000-0003-2133-1493)
- Nikolaos Scarmeas (ORCID: https://orcid.org/0000-0001-6453-8908)
- Susanne Moebus (ORCID: https://orcid.org/0000-0002-0072-5410)
- Hilkka Soininen (ORCID: https://orcid.org/0000-0002-2785-9937)
- Raquel Puerta (ORCID: https://orcid.org/0000-0002-1191-5893)
- Willemijn J. Jansen (ORCID: https://orcid.org/0000-0001-9081-1496)
- Innocenzo Rainero (ORCID: https://orcid.org/0000-0001-6074-9628)
- Jakub Hort (ORCID: https://orcid.org/0000-0002-1080-3726)
- Ruth Frikke‐Schmidt (ORCID: https://orcid.org/0000-0003-4084-5027)
- Tenielle Porter (ORCID: https://orcid.org/0000-0002-7887-6622)
- Daniela Galimberti (ORCID: https://orcid.org/0000-0002-9284-5953)
- Nesrine Ben Salem
- Shumpei Niida (ORCID: https://orcid.org/0000-0002-6192-8035)
- Marco Aurélio Romano‐Silva (ORCID: https://orcid.org/0000-0002-6558-4639)
- Shima Mehrabian (ORCID: https://orcid.org/0000-0002-3146-6001)
- Oriol Dols‐Icardo (ORCID: https://orcid.org/0000-0003-2656-8748)
- Brian W. Kunkle (ORCID: https://orcid.org/0000-0002-9515-5157)
- Pablo García‐González (ORCID: https://orcid.org/0000-0003-0125-5403)
- Simon M. Laws (ORCID: https://orcid.org/0000-0002-4355-7082)
- Han Cao (ORCID: https://orcid.org/0000-0001-9992-9108)
- Gaël Nicolas (ORCID: https://orcid.org/0000-0001-9391-7800)
- Fermín Moreno (ORCID: https://orcid.org/0000-0001-5200-3164)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Alison Goate (ORCID: https://orcid.org/0000-0002-0576-2472)
- Akinori Miyashita (ORCID: https://orcid.org/0000-0003-2508-9649)
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
- Thomas Tegos
- Vincenzo Solfrizzi (ORCID: https://orcid.org/0000-0002-8524-0315)
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
- Tatiana Forund
- Rui Zhang (ORCID: https://orcid.org/0009-0009-8928-6853)
- Rodrigo Pardo (ORCID: https://orcid.org/0000-0001-7411-5853)
- Qiong Yang (ORCID: https://orcid.org/0000-0002-3658-1375)
- Carlos Bustos (ORCID: https://orcid.org/0000-0002-1783-3063)
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- Luiz Armando De Marco
- Aude Nicolas
- Claudia Liliana Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Timo Grimmer
- Gerard D. Schellenberg
- Li-San Wang
- Jigyasha Timsina (ORCID: https://orcid.org/0000-0003-4794-9187)
- J. Michael Gaziano
- Antonio Daniele
- Carolina De La Cuesta
- Ana Gabriela Concha Mera
- Jean‐François Dartigues
- Latchezar Traykov
- Fabrizio Piras
- Florence Pasquier
- Benjamin Grenier‐Boley (ORCID: https://orcid.org/0009-0004-3412-3997)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Tunis University (TN)
- Universidade Federal de Minas Gerais (BR)
- Boston University (US)
- Edith Cowan University (AU)
- Universitat Autònoma de Barcelona (ES)
- Uppsala University (SE)
- University of Copenhagen (DK)
- University of Parma (IT)
- Alzheimer's Association (US)
- Oslo University Hospital (NO)
- Brigham and Women's Hospital (US)
- Centre National de la Recherche Scientifique (FR)
- National Institutes of Health (US)
- Universidad de Cantabria (ES)
- University Health Network (CA)
- University Medical Center Groningen (NL)
- Karolinska University Hospital (SE)
- University of Helsinki (FI)
- Vrije Universiteit Brussel (BE)
- University of Bonn (DE)
- Harvard University (US)
- Instituto Federal de Educação, Ciência e Tecnologia de Minas Gerais (BR)
- University of Lisbon (PT)
- University of Nottingham (GB)
- University of Miami (US)
- University of Thessaly (GR)
- Radboud University Nijmegen (NL)
- Uniformed Services University of the Health Sciences (US)
- University of Antwerp (BE)
- Université de Bordeaux (FR)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Chosun University (KR)
- University of Leicester (GB)
- University of Auckland (NZ)
- Inserm (FR)
- Universität Hamburg (DE)
- Tokyo University of Science (JP)
- Bangor University (GB)
- Stockholm University (SE)
- Mexican Social Security Institute (MX)
- The University of Texas at San Antonio Health Science Center (US)
- University of Monastir (TN)
- University of Cagliari (IT)
- University of Eastern Finland (FI)
- University of California, San Francisco (US)
- University of Cologne (DE)
- University of Oslo (NO)
- University of Milan (IT)
- Université de Montpellier (FR)
- Universidade de Santiago de Compostela (ES)
- Hong Kong University of Science and Technology (HK)
- National and Kapodistrian University of Athens (GR)
- University of Washington (US)
- University of Zurich (CH)
- Washington University in St. Louis (US)
- Norwegian University of Science and Technology (NO)
- Curtin University (AU)
- Adolfo Ibáñez University (CL)
- Charles University (CZ)
- Aristotle University of Thessaloniki (GR)
- Heidelberg University (DE)
- Université de Lille (FR)
- University of Cambridge (GB)
- Universidad de Buenos Aires (AR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- University of Perugia (IT)
- Université Paris-Saclay (FR)
- Alexandrovska Hospital (BG)
- University Hospital Bonn (DE)
- Stavanger University Hospital (NO)
- Helsinki University Hospital (FI)
- Hospital Universitario La Paz (ES)
- Institut Pasteur de Lille (FR)
- McLean Hospital (US)
- Instituto de Salud Carlos III (ES)
- German Center for Neurodegenerative Diseases (DE)
- Privatsykehuset Haugesund (NO)
- VA Boston Healthcare System (US)
- Fundación Instituto Leloir (AR)
- Hospital de Sant Pau (ES)
- Clínica Alemana (CL)
- University of Washington Medical Center (US)
- Erasmus MC (NL)
- Sykehuset i Vestfold (NO)
- Agostino Gemelli University Polyclinic (IT)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- TUM Klinikum (DE)
- Rigshospitalet (DK)
- Radboud University Medical Center (NL)
- Namsos Hospital (NO)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Karolinska Institutet (SE)
- El Hospital General de Agudos Carlos G. Durand (AR)
- Medical University of Sofia (BG)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- University Medical Center Utrecht (NL)
- Centre Hospitalier Universitaire de Lille (FR)
- LMU Klinikum (DE)
- Hospital Universitari i Politècnic La Fe (ES)
- Donauspital (AT)
- Universitat Internacional de Catalunya (ES)
- UNSW Sydney (AU)
- Harokopio University of Athens (GR)
- Maastricht University (NL)
- University of Cyprus (CY)
- ETH Zurich (CH)
- University of Bristol (GB)
- Universidad Nacional de Colombia (CO)
- University of California San Diego (US)
- Humboldt-Universität zu Berlin (DE)
- Swansea University (GB)
- Finnish Institute for Health and Welfare (FI)
- Sorbonne Université (FR)
- University of Oxford (GB)
- Centre National de Recherche en Génomique Humaine (FR)
- Data Tecnica International (United States) (US)
- Neuropsychiatrie : Recherche Epidemiologique et Clinique (FR)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Universitätsklinikum Erlangen (DE)
- Instituto de Salud Pública de Chile (CL)
- Hospital Universitari de Santa Maria (ES)
- Kuopio University Hospital (FI)
- Stockholm South General Hospital (SE)
- University Hospital Mútua de Terrassa (ES)
- HKUST Shenzhen Research Institute (CN)
- Assistance Publique – Hôpitaux de Paris (FR)
- University Hospital in Motol (CZ)
- Hospital Universitario de Gran Canaria Doctor Negrín (ES)
- Hospital del Salvador (CL)
- Zimmer Biomet (Germany) (DE)
- VA San Diego Healthcare System (US)
- Marqués de Valdecilla University Hospital (ES)
- Biogipuzkoa Health Research Institute (ES)
- University Hospital of Zurich (CH)
- University Hospital Brno (CZ)
- Dementia Collaborative Research Centres (AU)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Hospital La Paz Institute for Health Research (ES)
- National Center for PTSD (US)
- St Olav's University Hospital (NO)
- Central Institute of Mental Health (DE)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Normandie Université (FR)
- Bordeaux Population Health (FR)
- Hôpital Broca (FR)
- Amsterdam Neuroscience (NL)
- University Medical Center Hamburg-Eppendorf (DE)
- Ministry of Health (CL)
- Radboud Institute for Molecular Life Sciences (NL)
- Azienda Ospedaliera San Gerardo (IT)
- Occupational Cancer Research Centre (CA)
- Centro Andaluz de Biología del Desarrollo (ES)
- Institute for Neurodegenerative Disorders (US)
- University of Bangui (CF)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Munich Cluster for Systems Neurology (DE)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Centre Hospitalier et Universitaire de Brazzaville (CG)
- Hospital Clínic de Barcelona (ES)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Don Carlo Gnocchi Foundation (IT)
- Essen University Hospital (DE)
- Centro Medico Nacional Siglo XXI (MX)
- Pitié-Salpêtrière Hospital (FR)
- Framingham Heart Study (US)
- Fundación Pública Galega de Medicina Xenómica (ES)
- Swiss Integrative Center for Human Health (CH)
- Fundació ACE (ES)
- Universitätsklinikum Würzburg (DE)
- UK Dementia Research Institute (GB)
- Universitair Ziekenhuis Brussel (BE)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- CEA Paris-Saclay (FR)
- Mútua Terrassa (ES)
- Hospital Clínico de la Universidad de Chile (CL)
- Dr. John T. Macdonald Foundation (US)
- VIB-UAntwerp Center for Molecular Neurology (BE)
- Instituto de Biomedicina de Sevilla (ES)
- Instituto de Investigación Biomédica de Lleida (ES)
- Hospital Universitario Central de Asturias (ES)
- Hospital das Clínicas da Universidade Federal de Minas Gerais (BR)
- MRC Prion Unit (GB)
- St. Anne's University Hospital Brno (CZ)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Eginition Hospital (GR)
- Onkologikoa (ES)
- Centro de Biología Molecular Severo Ochoa (ES)
- Hospital Universitario de Valme (ES)
- Complex Engineering System Institute (CL)
- Stockholm Gerontology Research Center Foundation (SE)
- Instituto de Biomedicina de Valencia (ES)
- Center for Climate and Resilience Research (CL)
- Fondazione Santa Lucia (IT)
- Unidad Funcional de Investigación de Enfermedades Crónicas (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- Eisai (United States) (US)
- Amsterdam University Medical Centers (NL)
- Institut d’Epidémiologie Neurologique et de Neurologie Tropicale (FR)
- Ospedale Vito Fazzi (IT)
- Institut du Cerveau (FR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- University Hospital Cologne (DE)
- Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
- Greek Association of Alzheimer's Disease and Related Disorders (GR)
- Ontario Brain Institute (CA)
- National Center for Geriatrics and Gerontology (JP)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- VSL National Metrology Institute (NL)
- Instituto de Investigación Sanitaria del Principado de Asturias (ES)
- Institut de Recherche pour le Développement (FR)
- University of Southampton (GB)
- Alzheimer Precision Medicine (FR)
- University of Bergen (NO)
- University of Florence (IT)
- University College London (GB)
- Imperial College London (GB)
- Nottingham Trent University (GB)
- University of Turin (IT)
- University of Bari Aldo Moro (IT)
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- University of Duisburg-Essen (DE)
- Université de Rouen Normandie (FR)
- Technical University of Munich (DE)
- Tunis El Manar University (TN)
- Universidad Autónoma de Madrid (ES)
- Université de Limoges (FR)
- University of Milano-Bicocca (IT)
- University of Chile (CL)
- Niigata University (JP)
- The University of Tokyo (JP)
- Medical University of Vienna (AT)
- Columbia University (US)
- Charité - Universitätsmedizin Berlin (DE)
- Gwangju University (KR)
- Universidad de Sevilla (ES)
- Cardiff University (GB)
- University of Pennsylvania (US)
- University of Brescia (IT)
- Ludwig-Maximilians-Universität München (DE)
- Universidad de Málaga (ES)
- Vrije Universiteit Amsterdam (NL)
- University of Hong Kong (HK)
- Centro de Estudios Científicos (CL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Erasmus University Rotterdam (NL)
- Leipzig University (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Stanford University (US)
- University of Lausanne (CH)
- Delft University of Technology (NL)
- Icahn School of Medicine at Mount Sinai (US)
- KU Leuven (BE)
Publication Details
- Journal
- Nature Genetics
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1038/s41588-025-02227-w
- Citations
- 11
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 19.99
Funders
- EU Joint Programme – Neurodegenerative Disease Research
- Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease
- Université de Lille
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Fondation pour la Recherche sur Alzheimer