N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease
Thirteen differentially expressed intact N-glycopeptides were identified (p<0.05). Notably, we observed increased fucosylation (p<0.0001) and decreased N-acetylneuraminic acid (p<0.05) in ASS patients. In addition, specific glycosylation patterns correlated with lung function parameters. Our study revealed the IgG glycosylation profile in ASS patients and provided a valuable reference for further investigation of its potential diagnostic and prognostic applications.
Authors
- Tong Wu (ORCID: https://orcid.org/0000-0001-9968-9909)
- Yingying Ling (ORCID: https://orcid.org/0009-0006-2768-2410)
- Yinlan Wu (ORCID: https://orcid.org/0000-0002-0188-8676)
- Chunyu Tan (ORCID: https://orcid.org/0009-0004-1068-5995)
- Yi Liu (ORCID: https://orcid.org/0000-0002-3884-6605)
- Yong Zhang (ORCID: https://orcid.org/0000-0002-2692-5437)
- Cheng Lu (ORCID: https://orcid.org/0000-0002-8577-4288)
- Jing Zhao (ORCID: https://orcid.org/0000-0003-4919-0530)
- Deying Huang (ORCID: https://orcid.org/0000-0001-5891-4196)
- Yanhong Li
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1538219
- Citations
- 2
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China