Evidence for the role of Irk2 and Irk5 in ATP and metabolism regulation in Cryptococcus neoformans
This study suggests that the core virulence kinases Irk2 and Irk5 may play roles in regulating ATP levels and metabolic pathways. By elucidating the effects of these kinases on the proteomic and metabolomic profiles of <i>C. neoformans</i>, this research contributes to our understanding of the underlying molecular mechanisms involved in the pathogenesis of this pathogen.
Authors
- Mingming Xu (ORCID: https://orcid.org/0000-0002-8158-2879)
- Peng Xue (ORCID: https://orcid.org/0000-0003-2755-7987)
- Xiao‐Ya Chen (ORCID: https://orcid.org/0000-0002-2909-8414)
- Han Yu (ORCID: https://orcid.org/0000-0002-4229-0806)
- Jianhua Qu (ORCID: https://orcid.org/0000-0001-8171-9137)
- Yuanyuan Ma (ORCID: https://orcid.org/0000-0001-5410-4372)
- Nuoya Zhou
Institutions
- Nantong University (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fcimb.2025.1600041
- Citations
- 1
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province