sdrH enhances Staphylococcus aureus infection in diabetic wounds
This study presented that the <i>sdrH</i> gene enhances the virulence of <i>Staphylococcus aureus</i> in diabetic wounds by attenuating the host immune response, reducing the infiltration of inflammatory cells, and impairing the immune system's capacity to clear bacteria, thereby impeding the wound healing process. Although <i>icaA-C</i> is not a pivotal player, it seems to enhance the virulence capabilities of <i>sdrH</i>.
Authors
- Shijie Tang (ORCID: https://orcid.org/0000-0003-1580-3036)
- Jinmei Peng (ORCID: https://orcid.org/0000-0001-6943-6898)
- Kaiyu Nie (ORCID: https://orcid.org/0000-0003-1947-3652)
- Kaiyu Wang (ORCID: https://orcid.org/0000-0002-6580-9009)
- Wen Yin (ORCID: https://orcid.org/0000-0002-6619-5969)
Institutions
- Zunyi Medical University (CN)
- Shantou University (CN)
- Shantou University Medical College (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fmicb.2025.1502428
- Citations
- 2
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- Li Ka Shing Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province