Circ‐myh8/KAT7 Affects PANoptosis in Pulmonary Arterial Smooth Muscle Cells: Involvement of Super‐Enhancers in FOSL2 Expression
Circ-myh8 RNA, which functions jointly with KAT7, enhances H3K27ac enrichment, thereby promoting SE activity for FOSL2 transcription. This process ultimately contributes to the induction of PANoptosis in PASMCs. These findings elucidate the role of the circ-myh8/KAT7/SE/FOSL2 axis in the regulation of PANoptosis in PASMCs, thus offering new insights into the pathophysiology of PANoptosis in pulmonary hypertension. These findings may lead to novel therapeutic strategies for the treatment of pulmonary hypertension.
Authors
- Xiaodong Zheng (ORCID: https://orcid.org/0000-0002-6103-9836)
- Songyue Li (ORCID: https://orcid.org/0000-0001-7161-3881)
- Xinyue Song (ORCID: https://orcid.org/0000-0001-8238-309X)
- Xinru Wang (ORCID: https://orcid.org/0009-0001-4446-4961)
- Jing Qi (ORCID: https://orcid.org/0000-0002-9220-6852)
- Yibin Zhang
- Xu Wang (ORCID: https://orcid.org/0000-0002-8186-0947)
- Xu Ya
- Jingya Zhang (ORCID: https://orcid.org/0000-0002-2657-9802)
- Yan Xing (ORCID: https://orcid.org/0009-0006-0322-3228)
- Baoshan Zhao (ORCID: https://orcid.org/0000-0003-1583-3083)
- Shengjun Cao
- Jingming Hou (ORCID: https://orcid.org/0000-0002-8964-0359)
Institutions
- Harbin Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1161/jaha.124.040334
- Citations
- 3
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.56