Associations of different insulin resistance-related indices with the incidence and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study from UK biobank
Our findings highlight the critical role of IR-related indices, particularly TyG-WHtR and TyG-WC, in the incidence, progression, and prevention of CMM. The mediation effects of biomarkers indicate the potential for targeted interventions to reduce CMM risk in high-IR individuals.
Authors
- Fei Xue (ORCID: https://orcid.org/0000-0001-7047-8497)
- Yifei Li (ORCID: https://orcid.org/0000-0002-9503-3467)
- Lu Yang (ORCID: https://orcid.org/0000-0002-3955-150X)
- Jianmin Yang (ORCID: https://orcid.org/0000-0002-8593-2338)
- Yueqing Huang (ORCID: https://orcid.org/0000-0002-3443-5147)
- Zhenyu Tian (ORCID: https://orcid.org/0000-0003-0385-1460)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1186/s12933-025-02819-0
- Citations
- 31
- Primary Topic
- Chronic Disease Management Strategies
- Type
- article
- Field-Weighted Citation Impact
- 41.98
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation