Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype
Immune exclusion is responsible for intrinsic resistance to ICB in about half of nonresponder patients. Our unexpected observation that targeting NK cell biology unleashes the recruitment and antitumor activity of CD8+ T cells in tumors with an immune-excluded phenotype offers a potential therapeutic avenue for this large patient population. See related commentary by Galvez-Cancino et al., p. 1777 See related article by Song et al., p. 1835.
Authors
- Yvan Saeys (ORCID: https://orcid.org/0000-0002-0415-1506)
- Asier Antoranz (ORCID: https://orcid.org/0000-0001-7284-610X)
- Zihai Li (ORCID: https://orcid.org/0000-0003-4603-927X)
- Oliver Edgar Bechter (ORCID: https://orcid.org/0000-0003-0667-3284)
- Jean‐Christophe Marine (ORCID: https://orcid.org/0000-0003-2433-9837)
- No‐Joon Song (ORCID: https://orcid.org/0009-0002-0947-0597)
- Francesca M. Bosisio (ORCID: https://orcid.org/0000-0002-8874-2003)
- Lukas Vanwynsberghe (ORCID: https://orcid.org/0000-0002-3565-9900)
- Yannick Van Herck (ORCID: https://orcid.org/0000-0003-4604-8010)
- Philip Georg Demaerel (ORCID: https://orcid.org/0000-0002-0187-272X)
- Christos Gkemisis (ORCID: https://orcid.org/0000-0002-9889-8036)
- Robin Browaeys (ORCID: https://orcid.org/0000-0003-2934-5195)
- Niccolò Roda (ORCID: https://orcid.org/0000-0003-2798-2035)
- Veerle Boecxstaens (ORCID: https://orcid.org/0000-0001-5238-2619)
- Ewout Landeloos (ORCID: https://orcid.org/0000-0002-9128-6432)
- Joanna Poźniak (ORCID: https://orcid.org/0000-0001-5739-1098)
- Jeroen Declercq (ORCID: https://orcid.org/0000-0002-1244-7729)
- Patrick Matthys (ORCID: https://orcid.org/0000-0002-9685-6836)
- Diether Lambrechts (ORCID: https://orcid.org/0000-0002-3429-302X)
- Amber De Visscher (ORCID: https://orcid.org/0000-0002-9577-2390)
- Greet Bervoets (ORCID: https://orcid.org/0000-0003-2416-7246)
- Ayse Bassez (ORCID: https://orcid.org/0000-0002-0432-1536)
- Lotte Pollaris (ORCID: https://orcid.org/0000-0002-9509-9386)
Institutions
- HOGENT University of Applied Sciences and Arts (BE)
- Rega Institute for Medical Research (BE)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Universitair Ziekenhuis Leuven (BE)
- Ghent University (BE)
- VIB-KU Leuven Center for Cancer Biology (BE)
- Center for Human Genetics (US)
- VIB-UGent Center for Inflammation Research (BE)
- The Ohio State University (US)
- KU Leuven (BE)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1208
- Citations
- 13
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 13.59
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Stichting Tegen Kanker
- HORIZON EUROPE Marie Sklodowska-Curie Actions