Intravenous administration of mesenchymal stem cell-derived exosomes mitigates traumatic brain injury by inhibiting neutrophil extracellular trap formation via miR-26a-5p
These findings underscore the potential of MSC-Exos-miR-26a-5p to inhibit NET formation, modulate microglial polarization toward an anti-inflammatory phenotype, and enhance recovery from neural damage in TBI through the TAB2/JNK/AP1 pathway.
Authors
- Chao Peng (ORCID: https://orcid.org/0000-0002-6814-2676)
- Chengzi Yang (ORCID: https://orcid.org/0000-0002-0625-041X)
- Xianzheng Sang (ORCID: https://orcid.org/0009-0007-4621-314X)
- Yichao Ye (ORCID: https://orcid.org/0000-0001-7162-7642)
- Yun-Qing Li (ORCID: https://orcid.org/0000-0002-3707-3348)
- Danfeng Zhang (ORCID: https://orcid.org/0000-0003-2444-9227)
- Lijun Hou (ORCID: https://orcid.org/0000-0001-9877-1599)
- Hui Cai (ORCID: https://orcid.org/0000-0002-6584-2917)
- Wen Chen (ORCID: https://orcid.org/0000-0002-5008-1860)
- Xiaoxiang Hou (ORCID: https://orcid.org/0000-0002-9405-4995)
- Yangu Guo
- Hantong Shi
- Shi Yu (ORCID: https://orcid.org/0000-0002-7140-9327)
Institutions
- Shanghai Changzheng Hospital (CN)
- 303 Hospital of People's Liberation Army (CN)
Publication Details
- Journal
- Neuroreport
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1097/wnr.0000000000002187
- Citations
- 2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.59