Gestational glucocorticoid exposure impaired endothelial nitric oxide synthesis via downregulating IP3 receptor 3 expression in male offspring vessels
This study provides the first experimental evidence that gestational glucocorticoid exposure compromises endothelial NO synthesis in offspring vasculature through epigenetic reprogramming of IP3R3 gene expression. These novel findings demonstrate that the detrimental effects of antenatal glucocorticoid exposure on fetal vascular function persist into adulthood, offering critical insights into the developmental origins of vascular disease pathogenesis.
Authors
- Chenxuan Zhao (ORCID: https://orcid.org/0009-0009-5953-7893)
- Fengying Deng
- Junlan Qiu (ORCID: https://orcid.org/0000-0002-2058-5427)
- Meihua Zhang (ORCID: https://orcid.org/0000-0001-6160-1289)
- Qinqin Gao
- Jiahui Lei (ORCID: https://orcid.org/0000-0002-7032-2916)
Institutions
- Qingdao University (CN)
- National Health and Family Planning Commission (CN)
- Ruijin Hospital (CN)
- Soochow University (CN)
- Suzhou Municipal Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1097/hjh.0000000000004067
- Citations
- 1
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49