Betaine protects cerebral microvascular endothelium and ameliorates hypertension-induced cognitive dysfunction via upregulation of the endothelial nitric oxide synthase/nitric monoxide signaling pathway
Our findings suggest that betaine protects vascular endothelium and improves VCI by modulating the eNOS/NO signaling pathway.
Authors
- Jiale Sun (ORCID: https://orcid.org/0000-0002-8040-6267)
- Xiaomin Zhao (ORCID: https://orcid.org/0000-0002-1814-8586)
- Shan Gao (ORCID: https://orcid.org/0009-0002-4862-5942)
- Xueying Wang (ORCID: https://orcid.org/0000-0001-8979-3737)
- Wenjuan Zhang (ORCID: https://orcid.org/0000-0002-8850-5235)
Institutions
- Academy of Medical Sciences (GB)
- Ministry of Education of the People's Republic of China (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1097/hjh.0000000000004085
- Citations
- 2
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.68