Epigenetic study of the long-term effects of gulf War illness
Loss of myelin with accompanying musculoskeletal pain is a major symptom of Gulf War Illness. Our work demonstrates multiple genes were methylated by exposure to organophosphates and glucocorticoids. These genes point to biochemical mechanisms that may be targets for therapeutic intervention.
Authors
- James P. O’Callaghan (ORCID: https://orcid.org/0000-0001-8497-4598)
- Khyobeni Mozhui (ORCID: https://orcid.org/0000-0002-6623-4112)
- Pjotr Prins (ORCID: https://orcid.org/0000-0002-8021-9162)
- David G. Ashbrook (ORCID: https://orcid.org/0000-0002-7397-8910)
- Byron M. Jones (ORCID: https://orcid.org/0000-0002-4659-6976)
- L. Lü (ORCID: https://orcid.org/0000-0003-3089-8213)
- W. Zhao (ORCID: https://orcid.org/0000-0002-1787-4922)
Institutions
- University of Tennessee Health Science Center (US)
- National Institute for Occupational Safety and Health (US)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fgene.2025.1553410
- Citations
- 1
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Institutes of Health
- U.S. Public Health Service
- National Institute of Environmental Health Sciences