Atrial dysfunction: a contrast-free marker for HFpEF in obese diabetics—insights from comprehensive CMR and serum biomarker analyses
CMR markers of diffuse fibrosis and microvascular dysfunction may not differentiate HFpEF from obese or diabetic controls. However, left atrial function assessment may evolve to be a reproducible and practical CMR marker, effectively distinguishing HFpEF independent of fibrotic remodeling.
Authors
- Azizi Abu Bakar (ORCID: https://orcid.org/0000-0002-1177-9270)
- Frank Thomas Edelmann (ORCID: https://orcid.org/0000-0001-5209-0018)
- Maximilian Posch (ORCID: https://orcid.org/0000-0001-8649-9129)
- Seyedeh Mahsa Zamani
- Maximilian Leo Müller (ORCID: https://orcid.org/0000-0002-6281-9754)
- Dawn Cislak
- Stefanie Maria Werhahn (ORCID: https://orcid.org/0000-0002-0805-3129)
- Anita Y. H. Lee
- Amedeo Chiribiri (ORCID: https://orcid.org/0000-0003-3394-4289)
- Thomas J. McAvoy (ORCID: https://orcid.org/0000-0003-1157-9399)
- Christian Stehning (ORCID: https://orcid.org/0000-0002-0660-840X)
- Victoria Zieschang (ORCID: https://orcid.org/0000-0001-7474-2320)
- Rebecca Elisabeth Beyer (ORCID: https://orcid.org/0009-0007-9373-0756)
- An Bautmans
- Patrick Doeblin (ORCID: https://orcid.org/0000-0002-1511-8015)
- Sebastian Kelle (ORCID: https://orcid.org/0000-0001-8105-6599)
- Johannes Wieditz (ORCID: https://orcid.org/0000-0001-8601-0266)
- Radu Tanacli (ORCID: https://orcid.org/0000-0002-2193-9813)
- Djawid Hashemi (ORCID: https://orcid.org/0000-0003-3933-7092)
- John Palcza
- Carsten Tschöpe (ORCID: https://orcid.org/0000-0001-5243-8985)
- Xuemei Zhao (ORCID: https://orcid.org/0000-0003-0748-8777)
- Smita Sampath
- G. Brandon Atkins
- M Nassar
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Universitätsmedizin Göttingen (DE)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Philips (Germany) (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1186/s12933-025-02808-3
- Citations
- 3
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- Charité – Universitätsmedizin Berlin