Modified Zexie decoction improves phlegm-dampness type stage I hypertension by regulating the gut-immune-kidney axis
MZXD alleviates phlegm-dampness hypertension by modulating the gut-immune-kidney axis: enhancing microbial diversity, boosting SCFAs, attenuating inflammation, and improving renal function. This first systematic validation positions MZXD as a promising multi-target therapy. Future studies should explore clinical scalability and mechanistic depth.
Authors
- Bingbing Cheng (ORCID: https://orcid.org/0000-0002-1336-4781)
- Ning-Hua Jiang
- Yongqing Gu (ORCID: https://orcid.org/0000-0002-2211-8195)
- Yiyan Su
- Jiujie Jia
- Zeqi Hu
Institutions
- Zhejiang Chinese Medical University (CN)
- Jiaxing University (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fphar.2025.1578815
- Citations
- 2
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 2.23
Funders
- Science and Technology Bureau of Jiaxing City
- Medical Science and Technology Project of Zhejiang Province