Genetic evidence on the crucial role of immune cells in postpartum depression: Mendelian randomization analysis
The present study provides genetic evidence that IgD<sup>+</sup> B cells and CD25<sup>+</sup> IgD<sup>-</sup> CD38dim B cells exert protective effects against PPD through mechanisms involving immune regulation and neurodevelopment. These findings highlight the relevance of immune function in the pathophysiology of PPD and suggest promising targets for future therapeutic interventions.
Authors
- Xinghao Yu (ORCID: https://orcid.org/0000-0002-0589-0386)
- Lin Zhu (ORCID: https://orcid.org/0000-0002-4671-1129)
- Lijuan Wang (ORCID: https://orcid.org/0000-0003-1727-2670)
- Yi Jin (ORCID: https://orcid.org/0009-0004-8391-3178)
- Huimin Lu
- Yanfeng Hou (ORCID: https://orcid.org/0009-0000-5617-9917)
Institutions
- Jiangsu University (CN)
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Fourth People's Hospital of Changzhou (CN)
Publication Details
- Journal
- International Journal of Gynecology & Obstetrics
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1002/ijgo.70321
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00