Eucommia ulmoides seed oil is a complementary food for suppressing digestive tumors
EUSO attenuates the malignant progression of digestive system cancers by inhibiting the PI3K-AKT-mTOR pathway. These results provide mechanistic evidence supporting the potential application of EUSO as an adjuvant therapeutic agent in cancer management and warrant further clinical investigation into its chemopreventive and complementary therapeutic value.
Authors
- Shubing Zhang (ORCID: https://orcid.org/0000-0003-2819-8023)
- Bo Shu (ORCID: https://orcid.org/0000-0002-2428-009X)
- Durairaj Karthick Rajan
- Jinhua Yan (ORCID: https://orcid.org/0000-0003-3443-5267)
- Jinzheng Wu
- Hao Jiang (ORCID: https://orcid.org/0000-0002-9110-4723)
- Xin Yang (ORCID: https://orcid.org/0000-0003-3428-3806)
- Liang Wen
- Yan Liu (ORCID: https://orcid.org/0000-0003-3677-9290)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fphar.2025.1564999
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hunan Province
- National Natural Science Foundation of China