PXMP2 inhibits tumor stemness and immune infiltration in hepatocellular carcinoma based on stemness risk
This study identified three distinct stemness-based subtypes of HCC and established a novel three-gene prognostic risk model. Our findings highlight the critical role of PXMP2 in tumor biology and its potential as a therapeutic target, paving the way for personalized immunotherapy and chemotherapy approaches to enhance clinical outcomes in HCC patients.
Authors
- Shuai Mao (ORCID: https://orcid.org/0000-0003-0856-8007)
- Jiamu Qu
- Dingde Ye
- Runze Wang (ORCID: https://orcid.org/0000-0002-0542-3980)
- Jian Wang (ORCID: https://orcid.org/0000-0002-3106-5638)
- Ting Fang (ORCID: https://orcid.org/0000-0002-0474-0909)
- Jiaqing Chen (ORCID: https://orcid.org/0000-0001-9598-9701)
- Xianzhong He
- Qingxiang Xu
- Beicheng Sun
- Qing Ge
- Qiang Wang (ORCID: https://orcid.org/0009-0004-4325-6281)
Institutions
- Anhui University (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Anhui Mental Health Center (CN)
- Southeast University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1007/s12672-025-02976-4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Anhui Province