Genomic characterization of multidrug-resistant <i>Escherichia coli</i> with PBP3 insertions carrying <i>bla</i> <sub>NDM-5</sub> carbapenemase isolated from infants in Kenya
We report on carbapenem-resistant <i>Escherichia coli</i> ST46 and 167 strains isolated from fecal samples of 4- and 8-month-old infants, respectively, in Kenya, collected at discharge after more than 4 days of hospitalization. The isolates carried <i>bla</i><sub>NDM-5</sub> carbapenemase and a PBP3 (<sub>333</sub>YRIN/K<sub>334</sub>) insertion. This finding has implications for patient management.
Authors
- Kevin Kariuki (ORCID: https://orcid.org/0000-0001-6586-1504)
- Patricia B. Pavlinac (ORCID: https://orcid.org/0000-0002-0051-9131)
- Samuel Kariuki (ORCID: https://orcid.org/0000-0003-3209-9503)
- Judd L. Walson (ORCID: https://orcid.org/0000-0003-4836-720X)
- Polycarp Mogeni (ORCID: https://orcid.org/0000-0003-1926-7576)
- Doreen Rwigi (ORCID: https://orcid.org/0000-0002-0215-1887)
- Kirkby D. Tickell (ORCID: https://orcid.org/0000-0002-4108-1236)
- Collins K. Kigen (ORCID: https://orcid.org/0000-0002-4893-1213)
- Ferric C. Fang (ORCID: https://orcid.org/0000-0002-3243-110X)
- James Wachira (ORCID: https://orcid.org/0000-0001-7423-6743)
- Benson O. Singa (ORCID: https://orcid.org/0000-0002-6605-324X)
Institutions
- Johns Hopkins University (US)
- University of Washington (US)
- Kenya Medical Research Institute (KE)
- The Childhood Acute Illness and Nutrition Network (KE)
Publication Details
- Journal
- Microbiology Resource Announcements
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1128/mra.00121-25
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Allergy and Infectious Diseases