Correlation between endothelial dysfunction and sensorineural hearing loss

The study of biomarkers of endothelial dysfunction revealed that SNHL is characterized by impaired motor and adhesive function of vascular endothelium. Acute SNHL is more often characterized by an increase in the blood serum of the marker of vasospasm, endothelin-1 (ET-1), with the highest values (more than 0.5 pg/ml) detected in grade I and III hearing loss. On the contrary, chronic SNHL is characterized by an increase in blood serum markers of vascular endothelial adhesion disorders, namely fibrinogen and vascular endothelial adhesion molecules-1 (VCAM-1). Moreover, the highest values (more than 60 ng/ml) of the latter are found in grade II and III chronic SNHL.