BCAT1 Activation Reprograms Branched-Chain Amino Acid Metabolism and Epigenetically Promotes Inflammation in Diabetic Retinopathy
Bcat1 activation mediates BCAA metabolism remodeling in Müller cells and epigenetically induces retinal inflammation, which offers a potential therapeutic target for diabetic retinopathy. Diabetes and diabetic retinopathy are potentially driven not only by hyperglycemia but also by dysregulated amino acid metabolism.
Authors
- Sijun Sun
- Yiping Wang (ORCID: https://orcid.org/0000-0002-3178-3752)
- Xiaofang Tang (ORCID: https://orcid.org/0009-0002-2972-8778)
- Haiyan Wang (ORCID: https://orcid.org/0000-0001-8728-0719)
- Zihan Yin
- Shengjie Zhang (ORCID: https://orcid.org/0000-0003-4158-9010)
- Jingyi Wang (ORCID: https://orcid.org/0000-0002-2287-541X)
- Jingxiao Yang
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1167/iovs.66.6.59
- Citations
- 3
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.12
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China