Associations Between Myopia and Brain Volumes: An Observational and Genetic Analysis
Although myopia shows phenotypic associations with brain volumes, including total brain and white matter, and particularly with gray matter in individuals with lower education, genetic analysis (MR and GRS) did not support a causal or genetic link with brain volumes. These findings suggest that residual confounding factors beyond education level may underlie the observed associations between myopia and brain volumes, underscoring the need for further research to elucidate these relationships.
Authors
- Jiahao Liu (ORCID: https://orcid.org/0000-0002-9979-5805)
- Yu Huang (ORCID: https://orcid.org/0000-0002-3875-7581)
- Selena Wei Zhang
- Yanxian Chen (ORCID: https://orcid.org/0000-0002-5721-6051)
- Xianwen Shang (ORCID: https://orcid.org/0000-0001-6143-9349)
- Mingguang He (ORCID: https://orcid.org/0000-0002-6664-3442)
- Jie Guo (ORCID: https://orcid.org/0000-0001-8020-4481)
Institutions
- Hong Kong Polytechnic University (HK)
- The University of Melbourne (AU)
- Nanfang Hospital (CN)
- Centre for Eye Research Australia (AU)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1167/iovs.66.6.57
- Citations
- 2
- Primary Topic
- Ophthalmology and Visual Impairment Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Hong Kong Polytechnic University
- Joint Research Centre