The impact of de novo lipogenesis on predicting survival and clinical therapy: an exploration based on a multigene prognostic model in hepatocellular carcinoma
This study provided a novel prognostic model for HCC, incorporating 6 representative DNLs. The model demonstrated the potential for predicting HCC prognosis and highlighted the involvement of immune cell infiltration and the association between risk scores and clinical therapy. Validation of model genes further supported the association between de novo lipogenesis and HCC development.
Authors
- Hong Shen (ORCID: https://orcid.org/0000-0002-6456-8231)
- Xin Zhou (ORCID: https://orcid.org/0000-0002-7184-1101)
- Qingping Peng
- Erya Hu
- Yan Zhang (ORCID: https://orcid.org/0000-0002-0132-3325)
- Guangzu Cui
- Jiayao Ma (ORCID: https://orcid.org/0000-0001-6578-5935)
- Shan Zeng (ORCID: https://orcid.org/0000-0002-0988-723X)
- Xiangyang Zhang (ORCID: https://orcid.org/0000-0001-7873-1127)
- Yihong Chen (ORCID: https://orcid.org/0000-0002-7085-199X)
- Xinwen Wang (ORCID: https://orcid.org/0000-0001-8143-7017)
- Ying Han (ORCID: https://orcid.org/0000-0003-0377-7424)
- Li Yin (ORCID: https://orcid.org/0000-0002-5427-685X)
- Diya Tang
- Haicong Liu
Institutions
- Central South University (CN)
- Yueyang Second People's Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1186/s12967-025-06704-y
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province